abstract：PURPOSE:The identification of fibroblast-like cells of the marrow stroma by means of alkaline phosphatase (ALP) cytochemistry reveals delicate ALP-positive structures interspersed among haematopoietic cells and arranged in a loosely meshed network. These cells are often referred to as 'reticular' cells and the network ...

journal_title：International journal of radiation biology

authors： Almohamad K,Thiry A,Hubin F,Belaid Z,Humblet C,Boniver J,Defresne MP

更新日期：2003-04-01 00:00:00

abstract：PURPOSE:To determine the contribution of intra-alveolar cells as opposed to cells fixed in the interstitium in the development of radiation-induced lung injury. MATERIALS AND METHODS:C3H/HeN mice were irradiated to the thorax with various doses of radiation. The cellular composition and cytokine production were assess...

journal_title：International journal of radiation biology

authors： Hong JH,Jung SM,Tsao TC,Wu CJ,Lee CY,Chen FH,Hsu CH,McBride WH,Chiang CS

更新日期：2003-03-01 00:00:00

abstract：PURPOSE:To construct a quantitative model of the radiation-induced bystander effect based on diffusion-type spreading of bystander signal communication between the hit and non-hit cells. Cell inactivation and induced oncogenic transformation by broad- and microbeam irradiation systems are considered. MATERIALS AND MET...

journal_title：International journal of radiation biology

authors： Nikjoo H,Khvostunov IK

更新日期：2003-01-01 00:00:00

abstract：PURPOSE:To study the absorptive function of rat colon following whole-body exposure to neutron irradiation, either to the same total dose with varying proportion of neutrons or to the same neutron proportion with an increasing irradiation dose. MATERIALS AND METHODS:Different proportions of neutron irradiation were pr...

journal_title：International journal of radiation biology

authors： Dublineau I,Ksas B,Joubert C,Aigueperse J,Gourmelon P,Griffiths NM

更新日期：2002-12-01 00:00:00

abstract：PURPOSE:The relationship between cellular telephone use and excretion of the melatonin metabolite 6-hydroxymelatonin sulfate (6-OHMS) was evaluated in two populations of male electric utility workers (Study 1, n=149; Study 2, n=77). MATERIALS AND METHODS:Participants collected urine samples and recorded cellular telep...

journal_title：International journal of radiation biology

authors： Burch JB,Reif JS,Noonan CW,Ichinose T,Bachand AM,Koleber TL,Yost MG

更新日期：2002-11-01 00:00:00

abstract：PURPOSE:To evaluate and compare cytotoxic and mutational effects of graded doses of gamma-rays and 4He++ ions at different LET values (nominally 80 and 123 keV/microm) in V79 cells. MATERIALS AND METHODS:4He++ ion beams at 80 and 123 keV/microm were supplied by the 7 MV Van de Graaff CN accelerator of the INFN-LNL in ...

journal_title：International journal of radiation biology

authors： Cherubinit R,Canova S,Favaretto S,Bruna V,Battivelli P,Celotti L

更新日期：2002-09-01 00:00:00

abstract：PURPOSE:To investigate the relationship between the susceptibility of B-chronic lymphoid leukaemia (B-CLL) cells to DNA damage-induced apoptosis, the kinetics of DNA strand-break rejoining, and chromosome damage after exposure to ionizing irradiation. MATERIALS AND METHODS:Lymphocytes from B-CLL patients were gamma-ir...

journal_title：International journal of radiation biology

authors： Blaise R,Alapetite C,Masdehors P,Merle-Beral H,Roulin C,Delic J,Sabatier L

更新日期：2002-08-01 00:00:00

abstract：PURPOSE:To compare colony-forming and comet assays on fibroblasts and lymphocytes of 32 breast cancer patients irradiated after breast-conserving operations and to correlate the results with acute clinical radiation reactions in the skin. MATERIAL AND METHODS:Skin fibroblasts were isolated and cultivated before radiot...

journal_title：International journal of radiation biology

authors： Oppitz U,Schulte S,Stopper H,Baier K,Müller M,Wulf J,Schakowski R,Flentje M

更新日期：2002-07-01 00:00:00

abstract：PURPOSE:To determine whether murine lymphoid cell lines can discriminate between high- and low-LET (linear energy transfer) radiation-induced DNA lesions. MATERIALS AND METHODS:Sensitivity to killing by DNA-incorporated 3H and 125I decays, accumulated during storage in the gas phase of a liquid nitrogen tank, was dete...

journal_title：International journal of radiation biology

authors： Radford IR

更新日期：2002-06-01 00:00:00

abstract：PURPOSE:Estimating the absorbed dose to tumour relative to normal tissues has often been used in the assessment of the therapeutic efficacy of radiolabelled antibodies for radioimmunotherapy. Typically, the calculations assume a uniform dose deposition and response throughout the tumour. However, the heterogeneity of t...

journal_title：International journal of radiation biology

authors： Flynn AA,Pedley RB,Green AJ,Boxer GM,Boden R,Bhatia J,Morris R,Begent RH

更新日期：2002-05-01 00:00:00

abstract：PURPOSE:Up to 90% of hereditary breast cancer cases are linked to germ-line mutations in one of the two copies of the BRCA1 or BRCA2 genes. Brca1 and Brca2 proteins are both involved in the cellular defence against DNA damage, although the precise function of the proteins is still not known. Some studies on a small num...

journal_title：International journal of radiation biology

authors： Nieuwenhuis B,Van Assen-Bolt AJ,Van Waarde-Verhagen MA,Sijmons RH,Van der Hout AH,Bauch T,Streffer C,Kampinga HH

更新日期：2002-04-01 00:00:00

abstract：PURPOSES:To estimate the ratio of risks for exposure to radon progeny relative to low-LET radiation based on human lung cancer data, taking account of possible time and age variations in radiation-induced lung cancer risk. MATERIALS AND METHODS:Fitting two sorts of time- and age-adjusted relative risk models to a case...

journal_title：International journal of radiation biology

authors： Little MP

更新日期：2002-03-01 00:00:00

abstract：:A new approach is reported that combines synchrotron radiolysis and mass spectrometry to probe the structure of proteins. Hydroxyl radicals produced upon the radiolysis of protein solutions using synchrotron light modify amino acid side-chains on millisecond timescales. This results in the formation of stable oxidatio...

journal_title：International journal of radiation biology

authors： Kiselar JG,Maleknia SD,Sullivan M,Downard KM,Chance MR

更新日期：2002-02-01 00:00:00

abstract：PURPOSE:Ukrain, an alkaloid thiophosphoric acid derivative of Chelidonium majus L., has demonstrated a promising impact on chemotherapy in a variety of malignancies. The effects of the drug on cell survival, alteration of the cell cycle and induction of apoptosis were examined without and in combination with ionizing r...

journal_title：International journal of radiation biology

authors： Cordes N,Plasswilm L,Bamberg M,Rodemann HP

更新日期：2002-01-01 00:00:00

abstract：PURPOSE:To compare the chromosomal radiosensitivity of C3H mouse acute myeloid leukaemia (AML) cell lines 7926 and 8709 and to investigate the mechanistic basis of the radiosensitivity observed in 7926. MATERIALS AND METHODS:Yields of chromosome aberrations following X-irradiation were determined in Giemsa-stained met...

journal_title：International journal of radiation biology

authors： Finnon P,Wong HP,Silver AR,Slijepcevic P,Bouffler SD

更新日期：2001-12-01 00:00:00

abstract：PURPOSE:It has been previously argued that the use of the one-electron oxidants (SCN)2(*-) and Br2(*-) with plasmid DNA leads to the formation of DNA guanyl radicals. These guanyl radical species are intermediates in the DNA damage produced by processes such as photo-ionization and ionizing irradiation. The present pap...

journal_title：International journal of radiation biology

authors： Milligan JR,Aguilera JA,Mares EJ,Paglinawan RA,Ward JF

更新日期：2001-11-01 00:00:00

abstract：PURPOSE:To compare experimental yields of single strand breaks (SSB) and double strand breaks (DSB) induced in plasmid DNA in aqueous solution by alpha-particles and Al(K) ultrasoft X-rays (USX) with the corresponding yields, generated via computer simulations, for a range of mean diffusion distances of the hydroxyl ra...

journal_title：International journal of radiation biology

authors： Fulford J,Nikjoo H,Goodhead DT,O'Neill P

更新日期：2001-10-01 00:00:00

abstract：PURPOSE:To determine the involvement of c-Jun NH(2)-terminal kinase-1 (JNK1) and possibly of HSP27 in heat-induced apoptosis of human monoblastic leukaemia U937 cells. MATERIALS AND METHODS:Dominant negative JNK1 (APF), in which the phosphorylation sites Thr-Pro-Tyr were changed to Ala-Pro-Phe, was overexpressed in U9...

journal_title：International journal of radiation biology

authors： Enomoto A,Suzuki N,Liu C,Kang Y,Zhu J,Serizawa S,Matsumoto Y,Morita A,Ito M,Hosoi Y

更新日期：2001-08-01 00:00:00

abstract：PURPOSE:To evaluate the cumulative gamma-radiation personal exposure by analysing lymphocyte chromosome translocations using FISH painting and to compare FISH-derived biodoses with those derived from retrospective physical dose reconstruction in residents receiving chronic low dose-rate gamma-irradiation while living i...

journal_title：International journal of radiation biology

authors： Hsieh WA,Lucas JN,Hwang JJ,Chan CC,Chang WP

更新日期：2001-07-01 00:00:00

abstract：PURPOSE:To follow plasma Flt3-ligand (FL) concentrations in irradiated animals in order to evaluate it as an indicator of bone marrow damage for the management of accidental radiation-induced aplasia. MATERIALS AND METHODS:Non-human primates were irradiated at doses ranging from 2 to 8 Gy, using whole- or partial-body...

journal_title：International journal of radiation biology

authors： Bertho JM,Demarquay C,Frick J,Joubert C,Arenales S,Jacquet N,Sorokine-Durm I,Chau Q,Lopez M,Aigueperse J,Gorin NC,Gourmelon P

更新日期：2001-06-01 00:00:00

abstract：PURPOSE:Caffeine (1,3,7-trimethyl xanthine), a dietary component, has been shown to have widely varying effects on DNA damage induced by UV and ionizing radiation, depending upon pre- or post-irradiation administration and its concentration. Caffeine administered post-UV irradiation is known to inhibit enzymatic repair...

journal_title：International journal of radiation biology

authors： Kumar SS,Devasagayam TP,Jayashree B,Kesavan PC

更新日期：2001-05-01 00:00:00

abstract：PURPOSE:To evaluate the effects of 50 Hz magnetic fields (MF) on the development of cancer induced by ionizing radiation. MATERIALS AND METHODS:A total of 150 female CBA/S mice were randomized into three equal groups at the age of 3-5 weeks. One of the groups served as a 'cage-control group'. The two other groups were...

journal_title：International journal of radiation biology

authors： Heikkinen P,Kosma VM,Huuskonen H,Komulainen H,Kumlin T,Penttilä I,Väänänen A,Juutilainen J

更新日期：2001-04-01 00:00:00

abstract：PURPOSE:To investigate within the framework of a multilaboratory study the suitability of FISH chromosome painting to measure so-called stable translocations in peripheral lymphocytes of Mayak nuclear-industrial workers (from the Southern Urals) and their use for retrospective biodosimetry. MATERIALS AND METHODS:Chrom...

journal_title：International journal of radiation biology

authors： Bauchinger M,Braselmann H,Savage JR,Natarajan AT,Terzoudi GI,Pantelias GE,Darroudi F,Figgitt M,Griffin CS,Knehr S,Okladnikova ND,Santos S,Snigiryova G

更新日期：2001-03-01 00:00:00

abstract：PURPOSE:To investigate the possible role of cell cycle arrest in the radiosensitization of mouse spermatogonial stem cells due to small conditioning X-ray exposures. MATERIALS AND METHODS:A 24 h fractionation interval between conditioning (1 Gy) and challenging (8 or 9 Gy) exposures was used. Two approaches were follo...

journal_title：International journal of radiation biology

authors： Van Buul PP,Van Duyn-Goedhart A,Beumer T,Bootsma AL

更新日期：2001-03-01 00:00:00

abstract：PURPOSE:To evaluate the radioprotective activity of C3, a regioisomer of water-soluble carboxyfullerene and a potent free radical scavenger, on both normal and tumour cells. MATERIALS AND METHODS:The murine committed bone-marrow stem cells for both granulocytes and monocytes (GM-CFC) were used to represent normal cell...

journal_title：International journal of radiation biology

authors： Lin HS,Lin TS,Lai RS,D'Rosario T,Luh TY

更新日期：2001-02-01 00:00:00

abstract：PURPOSE:5-Formyluracil (5-foU) is a major derivative of thymine produced in DNA by ionizing radiation and various chemical oxidants. It has been previously shown that 5-foU in template DNA directs misincorporation of nucleotides by DNA polymerases during in vitro DNA synthesis. The present experiments were designed to ...

journal_title：International journal of radiation biology

authors： Miyabe I,Zhang QM,Sugiyama H,Kino K,Yonei S

更新日期：2001-01-01 00:00:00

abstract：PURPOSE:To carry out a comparative study on potential cytogenetic fingerprints for radiation LET in human metaphase lymphocytes. MATERIALS AND METHOD:Human lymphocytes were irradiated in vitro with 3.0 Gy 60Co gamma-rays, 0.9 Gy 3H beta-rays or 0.2 Gy 2.7 Mev neutrons. Detailed chromosome aberrations were analysed by ...

journal_title：International journal of radiation biology

authors： Deng W,Morrison DP,Gale KL,Lucas JN

更新日期：2000-12-01 00:00:00

abstract：PURPOSE:To investigate the induction of chromosomal aberrations in mouse m5S cells after exposure to power-line frequency magnetic fields (extremely low frequency magnetic fields; ELFMF) at high-flux densities. MATERIAL AND METHOD:m5S cells were either untreated or pretreated during the G1 phase with mitomycin C (MMC,...

journal_title：International journal of radiation biology

authors： Yaguchi H,Yoshida M,Ding GR,Shingu K,Miyakoshi J

更新日期：2000-12-01 00:00:00

abstract：PURPOSE:To determine the increases in SSB and DSB yields after post gamma-irradiation incubation of plasmid DNA with the Escherichia coli base excision repair endonucleases formamidopyrimidine-DNA N-glycosylase (FPG) and endonuclease III (endo III). MATERIALS AND METHODS:Aqueous solutions of plasmid DNA were irradiate...

journal_title：International journal of radiation biology

authors： Milligan JR,Aguilera JA,Nguyen TT,Paglinawan RA,Ward JF

更新日期：2000-11-01 00:00:00

abstract：PURPOSE:Ionizing radiation (IR) produced a dose-dependent increase in apoptosis in U937/pCEP4 cells which was attenuated by the stable over expression of Bcl-2 (U937/Bcl-2). A dose of 2 Gy IR was selected for further analyses to determine if subsequent exposure to 10nM bryostatin- would overcome the resistance to IR-in...

journal_title：International journal of radiation biology

authors： Cartee L,Davis C,Lin PS,Grant S

更新日期：2000-10-01 00:00:00

abstract：PURPOSE:To reduce retention and toxicity of the alpha particle emitter polonium-210 in rats by newly developed chelating agents. MATERIALS AND METHODS:Repeated subcutaneous chelation was conducted after intravenous injection of 210Po nitrate. For reduction of 210Po retention the treatment with vicinal dithiols meso-an...

journal_title：International journal of radiation biology

authors： Rencová J,Volf V,Jones MM,Singh PK

更新日期：2000-10-01 00:00:00

abstract：PURPOSE:To examine the relationship between cell killing and residual chromatin breaks after irradiation with qualitatively different types of radiation in six human cell lines. MATERIALS AND METHODS:Six human tumour cell lines and normal human cells were irradiated with 200 kV X-rays and two carbon-ion beams accelera...

journal_title：International journal of radiation biology

authors： Suzuki M,Kase Y,Kanai T,Ando K

更新日期：2000-09-01 00:00:00

abstract：PURPOSE:To investigate the mechanism of methylene blue-induced radiosensitization in Escherichia coli cells. MATERIALS AND METHODS:Bacteriophage lambda15 was irradiated with X-rays in the presence or absence of methylene blue (MB) and infected into bacteria with different repair capabilities preincubated with or witho...

journal_title：International journal of radiation biology

authors： Menezes S,Costa JA

更新日期：2000-09-01 00:00:00

abstract：PURPOSE:To investigate the potential total and relative free-radical transfer from histones to DNA in X-irradiated chromatin, by analysing the relative contributions of individual radicals from protein and from DNA. MATERIALS AND METHODS:Chromatin was isolated from calf thymus, freeze-dried and either used as such or ...

journal_title：International journal of radiation biology

authors： Weiland B,Hüttermann J

更新日期：2000-08-01 00:00:00

abstract：PURPOSE:To seek the delayed appearance of chromosomal abnormalities in human fibroblasts exposed to the Auger electron emitter 125I. MATERIALS AND METHODS:Normal untransformed human fibroblasts, HF19, were exposed to a concentration of [I125]IUdR, which allowed the survival of 37% of clonogens. Chromosomal analysis us...

journal_title：International journal of radiation biology

authors： Griffin CS,Neshasateh-Riz A,Mairs RJ,Wright EG,Wheldon TE

更新日期：2000-07-01 00:00:00

abstract：PURPOSE:Theoretical modelling techniques are often used to simulate the action of ionizing radiations on cells at the nanometre level. Using monoenergetic vacuum-UV (VUV) radiation to irradiate DNA either dry or humidified, the action spectra for the induction of DNA damage by low energy photons and the role of water a...

journal_title：International journal of radiation biology

authors： Folkard M,Prise KM,Vojnovic B,Brocklehurst B,Michael BD

更新日期：2000-06-01 00:00:00

abstract：PURPOSE:As the most recent epidemiological studies provide no definite conclusions about the effects of 50/60 Hz magnetic fields (MFs) on the incidence of leukaemia in humans, animal models in a well-controlled environment are useful for evaluating the possibility of an association between MFs and leukaemia. The presen...

journal_title：International journal of radiation biology

authors： Devevey L,Patinot C,Debray M,Thierry D,Brugere H,Lambrozo J,Guillosson JJ,Nafziger J

更新日期：2000-06-01 00:00:00

abstract：PURPOSE:To test whether radiolysis-induced fragmentation in frozen aqueous protein solution is dependent on solvent access to the surface of the protein or to the molecular mass of the polypeptide chain. MATERIALS AND METHODS:60Co gamma-irradiation of three proteins at -78 degrees C: lysozyme, citrate synthase and alp...

journal_title：International journal of radiation biology

authors： Audette M,Chen X,Houée-Levin C,Potier M,Le Maire M

更新日期：2000-05-01 00:00:00

abstract：PURPOSE:To study the influence of TGF-beta1 and TGF-beta-neutralizing antibodies on the clonogenic activity and terminal differentiation of rat lung fibroblasts following radiation exposure. MATERIAL AND METHODS:Early passage rat lung fibroblasts were used in this study. Colony formation assays were applied to determi...

journal_title：International journal of radiation biology

authors： Hakenjos L,Bamberg M,Rodemann HP

更新日期：2000-04-01 00:00:00

abstract：PURPOSE:To illustrate how probability-generating functions (PGFs) can be employed to derive a simple probabilistic model for clonogenic survival after exposure to ionizing irradiation. METHODS:Both repairable and irreparable radiation damage to DNA were assumed to occur by independent (Poisson) processes, at intensiti...

journal_title：International journal of radiation biology

authors： Kendal WS

更新日期：2000-04-01 00:00:00